Can antigen-specific regulatory T cells protect against graft versus host disease and spare anti-malignancy alloresponse?
Allogeneic hematopoietic cell transplantation provides effective control of hematopoietic malignancies, but with an associated risk of graft-versus-host disease (GVHD) related morbidity and mortality.Several advances in hematopoietic cell transplantation including high resolution HLA typing, development of reduced intensity conditioning regimens, i